Hostile creatures in red circle newly added in Baldur's Gate II: Enhanced Edition Shadows of Amn campaign.

Shank and Carbos in Candlekeep who start in blue are considered enemies because of their intention to assassinate the Ward and their fighting capacities. This standard should also apply to creatures like Larze in the Blushing Meraid, because although you may trick him to leave without him ever turning hostile, he’s still a bounty hunter for the Ward and is surely capable of fighting.

Animals like wild dogs, wolves are considered as enemies.

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